Diego Velázquez (1599–1660) was a Spanish painter.
Diego Velázquez or Diego Velásquez may also refer to:
- Diego Velázquez de Cuéllar (1465–1524), Spanish conquistador
- Diego Velazquez (actor) (born 2001), American TV and film child actor
- Diego Velázquez, actor in Argentine films The Fish Child and The Long Night of Francisco Sanctis
- Diego Velásquez (golfer) (born 1987), Colombian professional golfer