Antoniou (Greek: Αντωνίου) is a Greek surname. Notable examples include:
- Kostas Antoniou, Greek footballer.
- Marios Antoniou, Greek footballer.
- Platon Antoniou, English-Greek photographer.
- Theodore Antoniou, Greek conductor and composer.
- Haris Antoniou, Greek-Cypriot singer and musician.
- Angeliki Antoniou, Greek director and screenwriter.
- Laura Antoniou, American novelist.
- Ria Antoniou, Greek model.
- Anaïs Antoniou, French-Greek photographer.