The 2016 San Francisco 49ers season was the franchise's 67th season in the National Football League, the 71st overall, the third playing its home games at Levi's Stadium, and the only season under head coach Chip Kelly. The season saw the 49ers attempting to rebound from their 5–11 record the previous year. However, this season would prove to be even worse than the previous, as the 49ers finished 2–14, with their only wins coming against their division rival Los Angeles Rams. The 49ers' record was their worst since 2004, when they also finished 2–14 (both wins that season were against the Arizona Cardinals). The 49ers' 1–7 home record tied the worst home record in franchise history (not including the strike-shortened 1982 season). As a result, the 49ers fired head coach Chip Kelly and general manager Trent Baalke.
The 49ers defense also set an NFL record by allowing a 100 yard rusher in seven straight games and easily finished last in the league in rush defense.
After the 2015 season ended, the 49ers fired Jim Tomsula as head coach. On January 14, 2016, the 49ers hired Chip Kelly as their head coach. Kelly had spent the previous three seasons as head coach for the Philadelphia Eagles and had been fired after a disappointing 7–9 Eagles season.
The 49ers entered free agency with the following:
The 49ers' preseason opponents and schedule were announced April 7, 2016.
Note: Intra-division opponents are in bold text.
The 49ers wore their black alternate uniforms for this game as part of Color Rush.
With the loss, the 49ers were mathematically eliminated from postseason contention for the third consecutive season. An attempted rally by the 49ers was stopped short of the end zone in the final seconds.
With the win, the 49ers snapped their 13-game losing streak and swept the Rams on the season, while going 0–13 against the rest of the league. With the Cleveland Browns standing 0–14 before this week, the 49ers win also ended the possibility of two teams finishing 1–15 for the first time.
With the loss, the 49ers ended their season 2–14, their worst record since 2004. This was Colin Kaepernick's last game as a 49er.