Lester Alvin Burnett (March 18, 1911 – February 16, 1967), better known as Smiley Burnette, was an American country music performer and a comedic actor in Western films and on radio and TV, playing sidekick to Gene Autry, Roy Rogers, and other B-movie cowboys. He was also a prolific singer-songwriter who could play as many as 100 musical instruments, some simultaneously. His career, beginning in 1934, spanned four decades, including a regular role on CBS-TV's Petticoat Junction in the 1960s.

Ladarian Smiley (raised in Monticello, FL) is an American student and football player. He is affiliated with the Secondary school.

Thomas Smiley (c. 1660 – 1689) was a Williamite defender during the Siege of Derry.

Smiley Bates (October 16, 1937 – January 8, 1997) was a Canadian country singer, songwriter, and musician. He recorded over forty albums throughout his career and sold over three million records worldwide. Bates also performed on radio stations, CJKL-FM and CKJB. He died of cancer on January 8, 1997 at Bent River in Muskoka, Ontario, Canada.

Sam Smiley (raised in Jacksonville, Florida) is an American student and football player. He plays for North Carolina Tar Heels and is affiliated with the National Collegiate Athletic Association.

Rickey Smiley For Real is an American reality television series that premiered on November 10, 2015, on TV One. The series follows the life of comedian and radio show host Rickey Smiley as he juggles between his career, fatherhood and personal life, with the two main settings being Birmingham, Alabama (his hometown) and Atlanta, Georgia (where he hosts his syndicated radio show).

Albert Smiley Williams (1849-1924) was an American Democratic politician. He served as the Mayor of Nashville, Tennessee from 1904 to 1906.

Tommie Belton Smiley, Jr. (born February 18, 1944) is a former American football player. Tom Smiley caught the first pass in Cincinnati Bengals history, a 2-yard reception from quarterback Dewey Warren on September 6, 1968.

Norman Bryce Smiley (30 March 1909 – 9 October 1968) was an English brewer and brewing executive who served as President of the Institute of Brewing.