Samuel Lee may refer to:

Samuel Lee is an American soccer player from Madison, Alabama who plays as a goalkeeper for the Beachside SC soccer team.

Samuel Lee (14 May 1783 – 16 December 1852) was an English Orientalist, born in Shropshire; professor at Cambridge, first of Arabic and then of Hebrew language; was the author of a Hebrew grammar and lexicon, and a translation of the Book of Job .

Lee Samuel Finn is an American astrophysicist working at the Pennsylvania State University. His research interests are in gravitational wave astronomy.

Samuel Lee (1625–1691) was an English Puritan academic and minister, late in life in New England.

Samuel Lee (March 18, 1803 – August 27, 1881) was an American minister, author, and state legislator.