Samuel or Sam Francis may refer to:

Sir Francis Samuel Drake, 1st Baronet (1729 – 19 October 1789) was an officer of the Royal Navy. He served during the Seven Years' War and the American War of Independence, rising to the rank of Rear-admiral of the Red.

Samuel Francis Glass (January 8, 1861 – April 6, 1925) was an insurance and real estate agent and political figure in Ontario, Canada. He represented Middlesex East in the House of Commons of Canada from 1913 to 1921 as a Conservative.