James Macpherson (Gaelic: Seumas MacMhuirich or Seumas Mac a' Phearsain; 27 October 1736 – 17 February 1796) was a Scottish writer, poet, literary collector and politician, known as the "translator" of the Ossian cycle of epic poems. He was the first Scottish poet to gain an international reputation.

Sir James MacPherson Le Moine (24 January 1825 — 5 February 1912) was a Canadian author and barrister.

James MacPherson (born September 2, 1980) is a former American football quarterback who played two seasons in the Arena Football League (AFL) with the Georgia Force and Grand Rapids Rampage. He played college football at Wake Forest University. He was also a member of the Indianapolis Colts, Hamilton Tiger-Cats, Colorado Crush, Philadelphia Soul and Green Bay Blizzard.

James Macpherson (died 1932) was a British trade unionist.

James Macpherson (1736–1796) was a Scottish poet.