Francis G. Slay (born March 18, 1955) is an American politician and lawyer who served as the 45th Mayor of St. Louis, Missouri from 2001 to 2017. The first mayor of the city of St. Louis to be elected to the office four consecutive times, Slay is the longest-serving mayor in St. Louis history. His fourth term started in April 2013. He announced on April 8, 2016 that he would not seek another term as mayor. He is registered in the Democratic Party.

Charles Francis Bishop (August 2, 1888 – February 1, 1954) was a United States Navy sailor received the Medal of Honor for actions on board the USS Florida during the Veracruz Campaign.

Francis Komla Ganyaglo (born May 11, 1971) is a Ghanaian politician and the deputy Volta Regional Minister of Ghana .

Francis Joseph McCabe (May 3, 1936 - March 15, 2014) was a manufacturing company executive, inventor, pilot and an environmentalist. He was the founder of Prefco Products, a fire and smoke damper manufacturer and also designed the world’s fastest and lowest wind-responding wind-turbine airfoil.

David Francis Hickey, S.J. (December 3, 1882 – August 24, 1973) was an American-born bishop of the Catholic Church. He served as the Vicar Apostolic and then the first Bishop of Belize, from 1948-1957.

Francis Olaki is a Ugandan professional footballer, who plays as a Forward for Extension Gunners FC in Botswana .

Dumaka Francis Ifeanyi (born 3 August 1989) is a Nigerian football player who plays as an Attacker for Chumpon FC