Charles Drain may refer to:

Charles Drain (December 28, 1816 – June 24, 1894) was a politician in the Oregon Territory and later the U.S. state of Oregon, and the founder of the city of Drain. He was born in 1816 near Lancaster, Pennsylvania. The family moved to Shelby County, Indiana, when Charles was five. Both parents soon died. He married Nancy Ensley in 1839, and in 1852 the family moved to Marion County, Oregon, and later to Linn County, to farm in the Willamette Valley.

Charles Duncan Drain (January 24, 1913 – January 27, 1991) was a politician from Alberta, Canada. He served in the Legislative Assembly of Alberta from 1967 to 1975 as a member of the Social Credit caucus in both government and opposition.

Job Henry Charles Drain VC (15 October 1895 – 26 July 1975) was an English recipient of the Victoria Cross, the highest and most prestigious award for gallantry in the face of the enemy that can be awarded to British and Commonwealth forces.