Charles Cavendish may refer to:

Charles Cavendish (1620–1643) was an English royalist general, killed at the battle of Gainsborough.

Charles Cavendish, Viscount Mansfield (c. 1626 – June 1659) was an English politician who sat in the House of Commons from 1640 to 1644. He supported the Royalist cause in the English Civil War.